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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN1
All Species:
18.18
Human Site:
S104
Identified Species:
30.77
UniProt:
P49768
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49768
NP_000012.1
467
52668
S104
V
A
T
I
K
S
V
S
F
Y
T
R
K
D
G
Chimpanzee
Pan troglodytes
XP_001149972
443
50485
V97
T
L
C
M
V
V
V
V
A
T
I
K
S
V
S
Rhesus Macaque
Macaca mulatta
XP_001088524
384
43068
D38
I
Y
T
P
F
T
E
D
T
E
T
V
G
Q
R
Dog
Lupus familis
XP_547503
717
78133
D320
A
A
Q
W
R
S
Q
D
S
E
E
D
F
E
D
Cat
Felis silvestris
Mouse
Mus musculus
P49769
467
52621
S104
V
A
T
I
K
S
V
S
F
Y
T
R
K
D
G
Rat
Rattus norvegicus
P97887
468
52771
S104
V
A
T
I
K
S
V
S
F
Y
T
R
K
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
R109
V
A
T
I
K
S
V
R
F
Y
T
E
K
N
G
Chicken
Gallus gallus
Q4JIM4
468
52812
S105
V
A
T
I
K
S
V
S
F
Y
T
R
K
D
G
Frog
Xenopus laevis
O12976
433
48282
D87
I
Y
T
P
F
T
E
D
T
E
S
V
G
Q
R
Zebra Danio
Brachydanio rerio
Q9W6T7
456
50963
Y104
K
D
G
Q
Q
L
I
Y
T
P
F
R
E
D
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
S126
V
A
T
I
N
S
I
S
F
Y
N
S
T
D
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
G98
T
D
S
I
V
E
K
G
L
M
S
L
G
N
A
Sea Urchin
Strong. purpuratus
XP_001178715
518
58077
F137
A
T
I
S
T
V
S
F
Y
T
E
S
G
D
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64668
453
49290
F104
H
Y
M
R
F
S
A
F
F
V
L
G
T
M
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
82.2
46.2
N.A.
92.7
92.5
N.A.
62.3
82.2
77.3
70.8
N.A.
47.6
N.A.
49
55.6
Protein Similarity:
100
90.7
82.2
52
N.A.
96.5
96.5
N.A.
73.6
89.7
83
79
N.A.
63.4
N.A.
64
68.1
P-Site Identity:
100
6.6
13.3
13.3
N.A.
100
100
N.A.
80
100
6.6
13.3
N.A.
60
N.A.
6.6
6.6
P-Site Similarity:
100
20
26.6
26.6
N.A.
100
100
N.A.
86.6
100
26.6
33.3
N.A.
66.6
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
50
0
0
0
0
8
0
8
0
0
0
0
0
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
15
0
0
0
0
0
22
0
0
0
8
0
50
8
% D
% Glu:
0
0
0
0
0
8
15
0
0
22
15
8
8
8
0
% E
% Phe:
0
0
0
0
22
0
0
15
50
0
8
0
8
0
0
% F
% Gly:
0
0
8
0
0
0
0
8
0
0
0
8
29
0
43
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
0
8
50
0
0
15
0
0
0
8
0
0
0
0
% I
% Lys:
8
0
0
0
36
0
8
0
0
0
0
8
36
0
0
% K
% Leu:
0
8
0
0
0
8
0
0
8
0
8
8
0
0
0
% L
% Met:
0
0
8
8
0
0
0
0
0
8
0
0
0
8
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
8
0
0
15
0
% N
% Pro:
0
0
0
15
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
8
8
8
0
8
0
0
0
0
0
0
15
0
% Q
% Arg:
0
0
0
8
8
0
0
8
0
0
0
36
0
0
15
% R
% Ser:
0
0
8
8
0
58
8
36
8
0
15
15
8
0
8
% S
% Thr:
15
8
58
0
8
15
0
0
22
15
43
0
15
0
8
% T
% Val:
43
0
0
0
15
15
43
8
0
8
0
15
0
8
15
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
22
0
0
0
0
0
8
8
43
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _